Lawrence, 22, fresh off her Best Actress Oscar win, earned five nominations, including three with her Silver Linings Playbook costar Bradley Cooper for best musical moment, best kiss and best on-screen duo.
Django Unchained and Ted led the pack with seven nominations each.
But it was thumbs down for vampires Bella, Edward and Breaking Dawn, which received just one nomination – for Taylor Lautner, who received a nod for best shirtless performance.
In previous years, the Twilight films earned 23 nominations combined and 16 wins, including best kiss for Robert Pattinson and Kristen Stewart.
Movie of the year picks included: Django Unchained, Silver Linings Playbook, Ted, The Avengers and The Dark Knight Rises.
Actress Rebel Wilson, who earned two nominations for her performance in Pitch Perfect, will host this year's show on April 14.
Fans can see all the nominees and vote for their favorites at MTV.com.
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