The Oscar host, who is also nominated for Best Actor at Sunday's show, already won a best actor award this weekend – at the Independent Spirit Awards on Saturday.
"I just went through film school at NYU and finished my thesis film, so independent film means a lot to me," said the actor, who was nominated for his role in 127 Hours as real life adventurer Aron Ralston, who had to sever his own arm when he got trapped under a boulder in 2003.
Natalie Portman, the heavily favored frontrunner for Oscar's Best Actress award, took home the Spirit award for female acting for Black Swan, which also won for best picture and best director for Darren Aronosky on Saturday.
The Oscar Best Picture favorite, The King's Speech, nabbed the Spirit prize for best foreign film.
Winter's Bone stars John Hawkes and actress Dale Dickey took home supporting actor awards.
Inside the Spirit AwardsThe wind gusted and the temperatures dropped outside at the Spirit awards, but inside a very pregnant Portman glowed as she made her way to her table and stopped to say a quick "hello" to fellow actresses Catherine Keener, Sarah Paulson and Amanda Peet. Liev Schreiber also headed to the table to chat with the group and was joined shortly after girlfriend Naomi Watts.
Meanwhile, Kate Walsh had a mini Grey's Anatomy reunion and caught up with former costar Sandra Oh.
Warren Beatty and wife Annette Bening were lovey-dovey throughout the show, as were Jon Hamm and longtime girlfriend Jennifer Westfeldt, who sat cozily huddled together at their table.
At one point Bening made time to greet Nicole Kidman with a long hug and to chat with her and husband Keith Urban during a commercial break.
With reporting by JENNIFER GARCIA and JESSICA WEDEMEYER
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