Album of the Year
- I Am... Sasha Fierce, Beyoncé
- The E.N.D., The Black Eyed Peas
- The Fame, Lady Gaga
- Big Whiskey And The Groogrux King, Big Whiskey And The Groogrux King
- WINNERFearless, Taylor Swift
Record of the Year
- "Halo," Beyoncé
- "I Gotta Feeling," The Black Eyed Peas
- WINNER "Use Somebody," Kings Of Leon
- "Poker Face," Lady Gaga
- "You Belong With Me," Taylor Swift
Song of the Year
- "Poker Face," Lady Gaga & RedOne, songwriters (Lady Gaga)
- "Pretty Wings," Hod David & Musze, songwriters (Maxwell)
- WINNER "Single Ladies (Put A Ring On It)," Thaddis Harrell, Beyoncé Knowles, Terius Nash & Christopher Stewart, songwriter (Beyoncé)
- "Use Somebody," Caleb Followill, Jared Followill, Matthew Followill & Nathan Followill,, songwriter (Kings Of Leon)
- "You Belong With Me," Liz Rose & Taylor Swift, songwriters (Taylor Swift)
Best New Artist
- WINNER Zac Brown Band
- Keri Hilson
- MGMT
- Silversun Pickups
- The Ting Tings
Pop Vocal Album
- WINNER The E.N.D., The Black Eyed Peas
- Breakthrough, Colbie Caillat
- All I Ever Wanted, Kelly Clarkson
- The Fray, The Fray
- Funhouse, Pink
Best Female Pop Vocal Performance
- "Hometown Glory," Adele
- WINNER "Halo," Beyoncé
- "Hot N Cold," Katy Perry
- "Sober," Pink
- "You Belong With Me," Taylor Swift
Best Male Pop Vocal Performance
- "This Time," John Legend
- "Love You," Maxwell
- WINNER "Make It Mine," Jason Mraz
- "I'm Yours," Jason Mraz
- "If You Don't Know Me By Now," Seal
- "All About The Love Again," Stevie Wonder
Best Pop Performance By A Duo Or Group
- WINNER "I Gotta Feeling," The Black Eyed Peas
- "We Weren't Born To Follow," Bon Jovi
- "Never Say Never," The Fray
- "Sara Smile," Daryl Hall & John Oates
- "Kids," MGMT
Best Rock Performance By A Duo Or Group
- Can't Find My Way Home, Eric Clapton & Steve Winwood
- Life In Technicolor II, Coldplay
- 21 Guns, Green Day
- WINNER Use Somebody, Kings Of Leon
- I'll Go Crazy If I Don't Go Crazy Tonight, U2
Rap Album
- Universal Mind Control, Common
- WINNER Relapse, Eminem
- R.O.O.T.S., Flo Rida
- The Ecstatic, Mos Def
- The Renaissance, Q-Tip
Rock Album
- Black Ice, AC/DC
- Live From Madison Square Garden, Eric Clapton & Steve Winwood
- WINNER 21st Century Breakdown, Green Day
- Big Whiskey And The Groogrux King, Dave Matthews Band
- No Line On The Horizon, U2
Country Album
- The Foundation, Zac Brown Band
- Twang, George Strait
- WINNER Fearless, Taylor Swift
- Defying Gravity, Keith Urban
- Call Me Crazy, Lee Ann Womack
Best Female Country Vocal Performance
- "Dead Flowers," Miranda Lambert
- "I Just Call You Mine," Martina McBride
- WINNER "White Horse," Taylor Swift
- "Just A Dream," Carrie Underwood
- "Solitary Thinkin'," Lee Ann Womack
Best Male Country Vocal Performance
- "All I Ask For Anymore," Trace Adkins
- "People Are Crazy," Billy Currington
- "High Cost Of Living," Jamey Johnson
- "Living For The Night," George Strait
- WINNER "Sweet Thing," Keith Urban
