Album of the Year
- Viva la Vida or Death and All His Friends, Coldplay
- Tha Carter III, Lil Wayne
- Year of the Gentleman, Ne-Yo
- WINNER Raising Sand, Robert Plant & Alison Krauss
- In Rainbows, Radiohead
Record of the Year
- "Chasing Pavements," Adele
- "Viva la Vida," Coldplay
- "Bleeding Love," Leona Lewis
- "Paper Planes," M.I.A.
- WINNER "Please Read the Letter," Robert Plant & Alison Krauss
Song of the Year
- "American Boy," William Adams, Keith Harris, Josh Lopez, Caleb Speir, John Stephens, Estelle Swaray & Kanye West, songwriters (Estelle featuring Kanye West)
- "Chasing Pavements," Adele Adkins & Eg White, songwriters (Adele)
- "I'm Yours," Jason Mraz, songwriter (Jason Mraz)
- "Love Song," Sara Bareilles, songwriter (Sara Bareilles)
- WINNER "Viva La Vida," Guy Berryman, Jonny Buckland, Will Champion & Chris Martin, songwriters (Coldplay)
Best New Artist
- WINNER Adele
- Duffy
- Jonas Brothers
- Lady Antebellum
- Jazmine Sullivan
Pop Vocal Album
- Detours, Sheryl Crow
- WINNER Rockferry, Duffy
- Long Road Out of Eden, Eagles
- Spirit, Leona Lewis
- Covers, James Taylor
Best Female Pop Vocal Performance
- WINNER "Chasing Pavements," Adele
- "Love Song," Sara Bareilles
- "Mercy." performed by Duffy
- "Bleeding Love," Leona Lewis
- "I Kissed a Girl," Katy Perry
- "So What," Pink
Best Male Pop Vocal Performance
- "All Summer Long," Kid Rock
- WINNER "Say," John Mayer
- "That Was Me," Paul McCartney
- "I'm Yours," Jason Mraz
- "Closer," Ne-Yo
- "Wichita Lineman," James Taylor
Best Pop Performance By A Duo Or Group With Vocals
- WINNER "Viva La Vida," Coldplay
- "Waiting In The Weeds," Eagles
- "Going On," Gnarls Barkley
- "Won't Go Home Without You," Maroon 5
- "Apologize," OneRepublic
Best Rock Performance By A Duo Or Group With Vocals
- Rock N Roll Train, AC/DC
- Violet Hill, Coldplay
- Long Road Out Of Eden. Eagles
- WINNER Sex On Fire, Kings Of Leon
- House Of Cards, Radiohead
Rap Album
- American Gangster, Jay-Z
- WINNER Tha Carter III, Lil Wayne
- The Cool, Lupe Fiasco
- Nas, Nas
- Paper Trail, T.I.
Rock Album
- WINNER Viva la Vida or Death and All His Friends, Coldplay
- Rock N Roll Jesus, Kid Rock
- Only By the Night, Kings of Leon
- Death Magnetic, Metallica
- Consolers of the Lonely, The Raconteurs
Country Album
- That Lonesome Song, Jamey Johnson
- Sleepless Nights, Patty Loveless
- WINNER Troubadour, George Strait
- Around the Bend, Randy Travis
- Heaven, Heartache and the Power of Love, Trisha Yearwood
Best Female Country Vocal Performance
- "For These Times," Martina McBride
- "What I Cannot Change," LeAnn Rimes
- WINNER "Last Name," Carrie Underwood
- "Last Call," Lee Ann Womack
- "This Is Me You're Talking To," Trisha Yearwood
Best Male Country Vocal Performance
- "You're Gonna Miss This," Trace Adkins
- "In Color," Jamey Johnson
- "Just Got Started Lovin' You," James Otto
- WINNER "Letter To Me," Brad Paisley
- "Troubadour," George Strait
